Hey ! regardez ce que j’ai trouvé, un homonyme qui a l’air de s’y connaître 🙂
Molecular Mechanisms of Early Lung Specification and Branching Morphogenesis
DAVID WARBURTON, SAVERIO BELLUSCI, STIJN DE LANGHE, PIERRE-MARIE DEL MORAL, VINCENT FLEURY, ARNAUD MAILLEUX, DENISE TEFFT, MATHIEU UNBEKANDT, KASPER WANG, AND WEI SHI
The “hard wiring” encoded within the genome that determines the emergence of the laryngotracheal groove and subsequently early lung branching morphogenesis is mediated by finely regulated, interactive growth factor signaling mechanisms that determine the automaticity of branching, interbranch length, stereotypy of branching, left-right asymmetry, and finally gas diffusion surface area. The extracellular matrix is an important regulator as well as a target for growth factor signaling in lung branching morphogenesis and alveolarization. Coordination not only of epithelial but also endothelial branching morphogenesis determines bronchial branching and the eventual alveolar-capillary interface. Improved prospects for lung protection, repair, regeneration, and engineering will depend on more detailed understanding of these processes. Herein, we concisely review the functionally integrated morphogenetic signaling network comprising the critical bone morphogenetic protein, fibroblast growth factor, Sonic hedgehog, transforming growth factor, vascular endothelial growth factor, and Wnt signaling pathways that specify and drive early embryonic lung morphogenesis.