Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling

Biochem Biophys Res Commun. 2007 Jul 13;358(4):968-975

Harada Y, Yokota C, Habas R, Slusarski DC, He X.

(Fz) seven-pass transmembrane receptors are receptors and function in a variety of developmental pathways. Here we identify retinoic acid-inducible gene-1, 2, 3, and 4 (1, 2, 3, and 4) as potential Fz binding proteins. RAIG proteins are seven-pass transmembrane receptors, and RAIG2, 3, and 4 are expressed in early . XRAIG2 can activate small GTPases, such as , , and , and , thus exhibit activities that overlap with non-canonical Wnt/Fz signaling. Injection of XRAIG2 mRNA into Xenopus embryo causes a severe shortened and bent body axis due to defective movements, reminiscent of abnormal non-canonical Wnt signaling. XRAIG2 affects convergent extension in -treated animal caps, which can be partially rescued by co-injection of a dominant-negative form of Cdc42. In zebrafish embryo, XRAIG2 also causes Ca(2+) flux, one of the consequences of non-canonical Wnt signaling. These results suggest a possible crosstalk/integration between Wnt/Frizzled and RAIG signal transduction pathways.

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