Wnt-5A/Ror2 Regulate Expression of XPAPC through an Alternative Noncanonical Signaling Pathway

Wnt-5A/Ror2 Regulate Expression of XPAPC through an Alternative Noncanonical Signaling Pathway

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Developmental Cell, Volume 12, Issue 5, 8 May 2007, Pages 779-792

Summary

, a member of the nontransforming class of ligands, is required for convergent extension movements in embryos. XWnt-5A knockdown phenocopies paraxial protocadherin (XPAPC) loss of function: involuted mesodermal cells fail to align mediolaterally, which results in aberrant movements and a selective inhibition of constriction. XWnt-5A depletion was rescued by coinjection of XPAPC RNA, indicating that XWnt-5A acts upstream of XPAPC. XWnt-5A, but not XWnt-11, stimulates XPAPC expression independent of the canonical Wnt/ pathway. We show that transcriptional regulation of XPAPC by XWnt-5A requires the receptor tyrosine kinase . XWnt-5A/Xror2 signal through and to activate the with the transcription factors and . The Wnt-5A/Ror2 pathway represents an alternative, distinct branch of noncanonical Wnt signaling that controls gene expression and is required in the regulation of convergent extension movements in Xenopus

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